By Thomas A. Buchholz, Eric A. Strom (auth.), David E. Wazer, Douglas W. Arthur, Frank A. Vicini (eds.)
Accelerated partial breast irradiation (APBI) is being quickly brought into the medical administration of early breast melanoma. APBI, actually, incorporates a variety of various options and ways that come with brachytherapy, intraoperative, and exterior beam ideas. there's presently no unmarried resource that describes those concepts and their scientific implementation. this article is a concise instruction manual designed to aid the clinician within the implementation of APBI. This features a evaluation of the rules that underlie APBI, a realistic and specified description of every strategy for APBI, a overview of present scientific result of APBI, and a overview of the occurrence and administration of therapy similar complications.
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Extra resources for Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation
2004) High-dose-rate brachytherapy alone versus whole-breast radiotherapy with or without tumor bed boost after breast-conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys 60(4):1173–1181 Ravdin PM, Siminoff IA, Harvey JA (1998) Survey of breast cancer patients concerning their knowledge and expectations of adjuvant therapy. J Clin Oncol 16:515–521 Romestaing P, Lehingue Y, Carrie C, et al. (1997) Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France.
Radiation Therapy Oncology Group, Philadelphia Kuske RR, Winter K, Arthur D, et al. ). Int J Radiat Oncol Biol Phys 54:(2 suppl. 1):A-151 Kuske RR, Winter K, Arthur DW, et al. (2004) Phase II trial of brachytherapy alone following lumpectomy for stage I or II breast cancer: Initial outcomes of RTOG 9517 (Abstr. 565). Proc Am Soc Clin Oncol 23 Lawenda BD, Taghian AG, Kachnic LA, et al. (2003) Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-doserate interstitial implant.
Conventional whole breast irradiation is supported by large robust randomized trials and decades of common clinical practice. In comparison, there are less than a thousand women treated with APBI that have been followed for more than ﬁve years, and this necessitates combining results from several single institutional trials. This underscores the need to support Phase III clinical trials that compare APBI to whole breast irradiation. In the interim, though, if APBI is to be offered to patients, the clinician must carefully acknowledge the controversy over the role of APBI in the management of early breast cancer, and thoroughly educate the patient as to the justiﬁcation for treating a partial breast target and the extent of clinical trial data currently available to support such an approach.
Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation by Thomas A. Buchholz, Eric A. Strom (auth.), David E. Wazer, Douglas W. Arthur, Frank A. Vicini (eds.)