David W. Loring, Kimford J. Meador, Gregory P. Lee, Don W.'s Amobarbital Effects and Lateralized Brain Function: The Wada PDF

By David W. Loring, Kimford J. Meador, Gregory P. Lee, Don W. King

ISBN-10: 1461228743

ISBN-13: 9781461228745

ISBN-10: 1461277043

ISBN-13: 9781461277040

The intracarotid amobarbital (or Amytal) approach is usually known as the Wada try in tribute to Juhn Wada, the surgeon who devised the process and played the 1st uncomplicated animal study and scientific reports with this system. Wada checking out has develop into an essential component of the pre­ operative overview for epilepsy surgical procedure. apparently, although, Wada at the beginning built this system as a method to evaluate language dominance in psychiatric sufferers so that electroconvulsant treatment may be utilized unilaterally to the non-dominant hemisphere. Epilepsy surgical procedure has matured as a plausible remedy for intractable seizures and isn't any longer confmed to some significant universities and clinical institutes. but, as is more and more transparent via analyzing the surveys of techniques utilized by epilepsy surgical procedure facilities (e.g., Rausch, 1987; Snyder, Novelly, & Harris, 1990), there isn't basically nice heterogeneity within the equipment used in the course of Wada checking out to evaluate language and reminiscence features, yet there additionally seems an absence of consensus concerning the theoretical assumptions, and maybe, even the objectives of this procedure.

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Additional resources for Amobarbital Effects and Lateralized Brain Function: The Wada Test

Sample text

Snyder & Novelly (1991) reported that of the 55 epilepsy surgery centers surveyed, 19 (29%) employed a stimulus-distractor approach, whereas 39 centers (71%) employed discrete item presentation. Few systematic studies examining Wada memory performance have been conducted. In her description of amobarbital memory testing and its role in identifying patients at risk for post-surgical global memory loss, Rausch (1987) Continuous Recognition Studies 37 referred to 2 proceedings of scientific presentations (Kl~l}Ve, Grabow & Trites, 1969; Milner, Branch & Rasmussen, 1962),2 book chapters (Engel, Crandall & Rausch, 1983; Milner, 1975), and 1 peer-reviewed journal article (Rausch, Fedio, Ary, Engel & Crandall, 1984).

The 2 left-handed patients had left visual half-field superiority. These results were then compared to the Wada language fmdings in order to evaluate the potential for individual patient prediction, and all 13 right-handed patients with a half-field asymmetry were left cerebral language dominant. One of 2 left-handed patients was right cerebral language dominant, and the other patient displayed bilateral language, with greater right than left representation. Although the authors acknowledged the difficulty of this technique in the identification of patients with bilateral language, they were encouraged that similar non-invasive testing might eventually be substituted for the Wada language evaluation.

The different options that may be pursued if a patient fails the Wada memory test are discussed. 24 Historical Background 25 Historical Background Wilder Penfield at the Montreal Neurological Institute first observed significant memory impairment associated with bilateral temporal lobe dysfunction in 1951-1952. Penfield noted significant recent memory deficits following left temporal lobectomy in 2 patients who were postulated to have additional pre-existing right temporal lobe damage (Penfield & Milner, 1958).

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Amobarbital Effects and Lateralized Brain Function: The Wada Test by David W. Loring, Kimford J. Meador, Gregory P. Lee, Don W. King


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