By Morton Rothstein
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Extra resources for Biochemical Approaches to Aging
And Cummings, D. J. (1976a). Mech. Ageing Dev. 5, 139-154. , and Cummings, D. J. (1976b). Mech. Ageing Dev. 5, 3 2 5 - 3 3 8 . , and Cummings, D. J. (1977). Mech. Ageing Dev. 6, 3 9 3 - 4 0 6 . Swim, Η. , and Parker, R. F. (1957). Am. ]. Hyg. 66, 2 3 5 - 2 4 3 . , and Yoshida, M. (1980). /. Cell Sci. 41, 1 7 7 - 1 9 1 . , and Kumahara, Y. (1980). Exp. Cell Res. 127, 185-190. Vincent, R. A. , and Huang, P. C. (1976). Exp. Cell Res. 102, 3 1 - 4 2 . Vincent, A. , Rodrick, G. , and Sodeman, W. A.
Age is defined as the number of mitotic divisions since cross-fertilization or self-fertilization. These processes set the fission clock back to zero. The organisms show a definite pattern of aging behavior (Sonneborn, 1954): an immature period in which the cell cannot undergo a sexual process; a period of maturity during which sexual processes decline; death. With increasing fission number, there is a gradually decreasing fission rate and an increased frequency of death of the progeny after autogamy.
Cohen, B. J. (1978). In "Development of the Rodent as a Model System of Aging" (D. C Gibson, R. C. Adelman and C. ), Book II, pp. 135-137. S. Department of Health, Education and Welfare. Publ No. 79-161. Coleman, G. , Barthold, S. , Osbaldiston, G. , Foster, S. , and Jonas, A. M. (1977). /. Gerontol. 32, 2 5 8 - 2 7 8 . Cristofalo, V. J. (1970). In "Aging in Cell and Tissue Culture" (E. Holeckova and V. J. ), pp. 8 3 - 1 1 9 . Plenum, New York. Cristofalo, V. J. (1972). Adv. Gerontol. Res. 4, 4 5 - 7 9 .
Biochemical Approaches to Aging by Morton Rothstein