Get Biological Reactive Intermediates—II: Chemical Mechanisms PDF

By Robert Snyder

ISBN-10: 147570674X

ISBN-13: 9781475706741

ISBN-10: 1475706766

ISBN-13: 9781475706765

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O ,l [ 2000 I 0~~----~~-------------C~~~--~~------~ dGuo 400 E a. I~ACETOXYESTRAGOLE +[14c] DEOXYGUANOSINE -o «t-0 200 0~®~~~~~~~~==~~~==~==~ 4000 MOUSE -LIVER DNA HYDROLYSATE E ll a. ;> 1000 o~~~----~~--~----~----~---L~~~----~ 5 10 15 20 25 30 35 40 MINUTES Fig. 7. HPLC profiles ~f hydrolysates of hepatic DNA from mice treated with [ H]l'-hydroxyestragole and of tj~ reaction mixture of 1'-acetoxyestf~gole reacted with [ C]deoxyguanosine {frame A) or [ C]deoxyadenosine {frame B) • The hepatic DNA hydrolysate and the in vitro reaction mixture were co-chromatographed on an-octadecylsilane column with acetonitrile-water.

Agarwal, S. , 1977, Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis, J. Toxicol. Environ. Health, 2:1297. Maher, V. , and McCormick, J. , 1979, DNA repair and carcinogenesis, in: "Chemical Carcinogens and DNA," P. L. , Vol. 2, p. 133, CRC Press, Boca Raton, Fla. Malling, H. , 13:425. Markert, C. , 1978, Cancer: The survival of the fittest, in: "Cell Differentiation and Neoplasia,h G. F. Saunders, ed:"", Raven Press, New York. Maugh, T. , Science, 199:162. , and Ames, B.

1976, Application of the change in partition coefficient with pH to the structure determination of alkyl substitute( guanosines, Biochem. Biophys. Res. , 73:459. O'Connor, P. , and Margison, G. , 1979, ~-Nitroso­ compounds: Biochemical mechanisms of action, in: "Environmental Carcinogenesis: Occurrence, Risk Evaluation, ana Mechanisms," P. Emmelot and E. , p. 73, Elsevier/North Holland, Amsterdam. , 1973, Mammalian epoxide hydrases: Inducible enzymes catalyzing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds, 20 E.

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Biological Reactive Intermediates—II: Chemical Mechanisms and Biological Effects by Robert Snyder


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