By Liang-Fu Zhou, Guohua Xi, Xian-Cheng Chen, Richard F. Keep, Feng-Ping Huang, Ya Hua, Yi-Cheng Lu, Karin Muraszko
Cerebral hemorrhage is a standard and sometimes deadly subtype of stroke. whereas long ago it has acquired rather little cognizance in comparison to ischemic stroke, there were significant advances in our figuring out of this devastating kind of stroke. The papers through global specialists conceal the sector from molecular biology to medical trials.
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Additional info for Cerebral Hemorrhage
Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB (2008) Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 15: 171–182 4. He Y, Wan S, Hua Y, Keep RF, Xi G (2008) Autophagy after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 28: 897–905 32 Y. : Induction of autophagy in rat hippocampus and cultured neurons by iron 5. Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, Xi G (2006) Long-term effects of experimental intracerebral hemorrhage: the role of iron.
Tang1 , J. Zhang1;2;3 1 Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA 3 Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA 2 Summary Free radical mechanisms are involved in secondary brain injury after intracerebral hemorrhage (ICH). Since melatonin is a potent free radical scavenger and indirect antioxidant, the objective of this study was to evaluate whether melatonin administration would attenuate oxidative stress, brain edema, and neurological deﬁcits in a rat model of ICH.
Materials and methods All the procedures used in our studies were in compliance with the Guide for the Care and Use of Laboratory Animals and approved by the Animal Care and Use Committee at Loma Linda University. Aseptic technique was used for all surgeries, and rats were allowed free access to food and water. Male Sprague-Dawley rats (290–395 g; Harlan, Indianapolis, IN, USA) were used for this study. Rats were anaesthetized with isoﬂurane and placed prone in a stereotaxic frame (Kopf Instruments, Tujunga, CA, USA).
Cerebral Hemorrhage by Liang-Fu Zhou, Guohua Xi, Xian-Cheng Chen, Richard F. Keep, Feng-Ping Huang, Ya Hua, Yi-Cheng Lu, Karin Muraszko