By R. D. Callander (auth.), Colin S. Cooper Ph. D., Philip L. Grover D. Sc. (eds.)
I were privileged to witness and perform the good development of data on chemical carcinogenesis and mutagenesis considering 1939 while I entered graduate college in biochemistry on the college of Wisconsin Madison. I instantly began to paintings with the carcinogenic aminoazo dyes un der the path of Professor CARL BAUMANN. In 1942 I joined a fellow graduate scholar, ELIZABETH CA VERT, in marriage and we quickly started a joyous half nership in examine on chemical carcinogenesis on the McArdle Laboratory for melanoma learn within the collage of Wisconsin clinical university in Madison. This collaboration lasted forty five years. i'm very thankful that this quantity is dedi cated to the reminiscence of Elizabeth. the $64000 and sundry subject matters which are reviewed right here attest to the continuing development of the fields of chemical vehicle cinogenesis and mutagenesis, together with their contemporary and fruitful union with viral oncology. i think very confident concerning the program of data in those fields to the eventual resolution of diverse difficulties, together with the detection and estimation of the dangers to people of environmental chemical cancer causing agents and re lated factors.
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Additional info for Chemical Carcinogenesis and Mutagenesis II
1987). The concentration of the S9 fraction used in such exogenous activation systems is also an important factor in the efficacy of the system. Whilst the original Salmonella assay protocol (AMEs et al. e. 20-50 ~l S9 per plate using standard assay protocols - see Sect. 1), the majority of practitioners routinely use 10% (50 ~l/plate), as evidenced by the first international collaborative study (cf. BRIDGES et al. 1981 and individual reports in the same volume). The example of the hair dye component 2-(2',4'-diaminophenoxy)ethanol being a mutagen to Salmonella only at high levels of S9 fraction in the S9-mix (VENITT et al.
Minimisation of loss of efficacy through extended storage and incubation at elevated temperatures should be considered when choosing a suitable preparative method. Data have been presented (HUBBARD et al. g. ethylmorphine-N-demethylase) can occur in as little as 5 days at storage temperatures of - 20°C. Similarly, prolonged standing at + 20 °C when thawing a frozen S9 sample can reduce the observed mutagenicity of a compound (HUBBARD et al. 1985). Although S9 fractions prepared by a standard technique from a consistent animal stock should give reproducible results for a known compound, monitoring of all enzyme pathways for every S9 preparation is not technically feasible: the possibility exists that the test chemical is activated by a metabolic pathway not checked by the normal control compounds.
In: Parry JM, Arlett CF (eds) Comparative genetic toxicology: the second UKEMS collaborative study. Macmillan, London, pp 413-438 ICPEMC (1982) International commission for protection against environmental mutagens and carcinogens: committee 2 final report. Mutagenesis testing as an approach to carcinogenesis. Mutat Res 99:73-91 Kada T, Tutikawa K, Sadaie Y (1972) In vitro and host-mediated "rec-Assay" procedures for screening chemical mutagens; and phloxine, a mutagenic red dye detected. Mutat Res 16:165-174 Kier LD, Yamasaki E, Ames BN (1974) Detection of mutagenic activity in cigarette smoke condensate.
Chemical Carcinogenesis and Mutagenesis II by R. D. Callander (auth.), Colin S. Cooper Ph. D., Philip L. Grover D. Sc. (eds.)