By John P. Bennett (auth.)
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However, it is more than likely that the concept was jointly developed by Sturgis and Albright (1940) from their attempts to use estrogens 23 COMBINATION AND SEQUENTIAL ORAL CONTRACEPTIVES for the relief of dysmenorrhea. Reynolds (1967) quotes from a letter by Sturgis, referring to this work: From 1936-40 I was a surgical assistant attached to Fuller Albright's Ovarian Dysfunction Clinic at the Massachusetts General Hospital. Albright was investigating a hormonal cause for severe primary dysmenorrhea.
With the hope that they will increase the efficacy or acceptability of low-dose hormonal contraception. These studies have resulted in several unique methods of contraceptive delivery that are suitable for combination or low-dose hormonal contraception. The use of intramuscular injections of steroids as depot contraceptives in appropriate formulaINJECTABLE HORMONAL CONTRACEPTIVES. 52 MINI PILL AND DEPOT HORMONAL CONTRACEPTIVES 50 40 CONTROL --LH ---- FSH 30 20 E "- ~ E 10 en z i: a. 6 Composite data of FSH and LH values during control and chlormadinone acetate cycles in nine women.
The Sequential Oral Contraceptive Regimen The sequential (or serial) oral contraceptive regimen was developed by Goldzieher and co-workers (1963) and by Liggins (1964). The estrogen (generally mestranol or ethinyl estradiol) is given as a daily tablet for 15 (or 16) days, starting on day 5 of the menstrual cycle, followed by a daily combination dose of estrogen mixed with progestin for 5 days. Placebo tablets are administered daily between the cessation of drug treatment on day 25 and the beginning of the next treatment sequence on day 5 of the succeeding menstrual cycle (fig.
Chemical Contraception by John P. Bennett (auth.)