By Ernst Freese (auth.), Alexander Hollaender (eds.)
As editor i need particularly to thank Dr. Ernst Freese for necessary co operation in getting ready those volumes, and to specific my appreclatlOn to Drs. Kurt Hirschhorn and Marvin Legator, the opposite participants of the editorial board. Alexander Hollaender January 1971 Preface the aim of those volumes is to motivate the improvement and ap plication of checking out and tracking tactics to evade major human publicity to mutagenic brokers. the necessity for cover opposed to publicity to in all probability mutagenic chemical compounds is barely now coming to be as a rule learned. The lately issued file of the Secretary's fee on insecticides and Their attainable results on well-being (the Mrak Report-U.S. division of wellbeing and fitness, schooling and Welfare, December 1969) has made an incredible begin. Its Panel on Mutagenicity recommends that every one presently used insecticides be confirmed for mutagenicity in different lately built and comparatively basic platforms. even if strategies comparable to those are literally implement depends on convincing govt, undefined, and the general public that the matter is necessary, that the proposed assessments will be potent, and they might be carried out at a value that's not prohibitive. Why is it very important to monitor environmental brokers for mutagenic job? to those that will learn this ebook, the answer's self-evident. The sine qua non of all that we price and all that we're is our genetic heritage.
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Additional info for Chemical Mutagens: Principles and Methods for Their Detection Volume 1
For example, 5-bromouracil is extremely sensitive to light, heat, or reducing chemicals which inactivate DNA containing this base analog; alkylating agents induce mutagenic DNA alterations by the alkylation of the 7 position of G and inactivating alterations either by the removal of the alkylated purines or by backbone breakage; hydroxylamine induces point mutations by reaction with C, but, in the presence of trace metals and oxygen, it also produces radicals which rapidly inactivate DNA (especially at low hydroxylamine concentrations, at which the compound cannot reduce the radicals again).
But unfortunately a significant number of mutations are not as deleterious; they express themselves as diseases or merely as a reduction in vitality. Since mankind has decided to eliminate natural selection among human beings, it is also responsible to reduce human misery by curtailing the propagation of detrimental traits and by eliminating environmental mutagens which can increase the frequency of such traits. III. A. DETECTION OF CHROMOSOME ABERRATIONS AND SYSTEMS OF GENETIC ANALYSIS Cytological Examination of Large Chromosome Aberrations Chromosome aberrations can be seen under the light microscope only in organisms whose chromosomes are sufficiently large that structural details can be carefully examined.
Various types of inactivating DNA alterations, which will be discussed in Molecular Mechanisms of Mutations 25 more detail in section V, are summarized in Fig. 7. Agents inducing inactivating DNA alterations also induce chromosome breaks and chromosome mutations, as would be expected as a consequence of the block in DNA synthesis. Most types of inactivating DNA alterations probably can be repaired by specific enzyme systems, as is shown by results for UV- and alkylation-induced breaks in bacteria and by the cytologically observed restitution of chromosome breaks.
Chemical Mutagens: Principles and Methods for Their Detection Volume 1 by Ernst Freese (auth.), Alexander Hollaender (eds.)