By Alvin M. Kaye
Focusses awareness on a facet of steroid hormone motion which delivers to carry an more and more vital position in destiny examine. Responsiveness happens in cells the place there's an it appears sufficient volume of the proper receptor, but very little reaction to the hormone. an answer to the tricky challenge of the way the Steroid-receptor complicated modulates RNA transcription could be present in half by way of a research of platforms within which the phenomenon of responsiveness is exhibited
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Extra info for Development of Responsiveness to Steroid Hormones. Advances in The Biosciences
Of six independent determinations. (From Maurer and Gorski, 1977) estradiol (Fig. 6 ) . Since the amount of estradiol available to cells is substan tially reduced due to steroid binding proteins in the serum (Westphal, 1961), the maximal effective dose in this system may be as low as 1-2 x ÎCT^M (cf. Pavlik and Katzenellenbogen, 1978). At a concentration of 10~9M, estradiol, estriol and diethylstilbestrol were equally stimulatory, while testosterone, 5a-dihydrotestosterone, progesterone and corticosterone had no significant effect on prolactin synthesis (Fig.
Nunez et al. Fig. 6. Effect of the "L" fraction from rat embryo serum on estrone (E,)-binding to rat AFP. 2 yg pure AFP were incubated with H-E. 01 ml of the "L" fraction. Free estrone was ad sorbed with dextran-charcoal and bound E, (B) counted. The concentration of free E. (F) was calculated by difference. ) Rodent AFP interation with estrogen 51 interesting to submit purified rat AFP to the pH 3-charcoal defatting procedure and examine the effect of this treatment on estrogen binding properties.
1971). Steroids, 21, 249. P. and M. Moguilewsky (1976). ). Système Nerveux, Activité Sexuelle et Reproduction. , Paris, pp. 85-92. , 0. A. A.
Development of Responsiveness to Steroid Hormones. Advances in The Biosciences by Alvin M. Kaye