Download e-book for kindle: Diagnosis and Management of Craniopharyngiomas: Key Current by Andrea Lania, Anna Spada, Giovanni Lasio

By Andrea Lania, Anna Spada, Giovanni Lasio

ISBN-10: 3319222961

ISBN-13: 9783319222967

ISBN-10: 331922297X

ISBN-13: 9783319222974

This publication presents updated insurance of the main appropriate issues within the analysis and administration of craniopharyngiomas. After introductory dialogue of normal historical past and medical presentation, person chapters are dedicated to pathological and molecular facets, use of diagnostic imaging innovations, the surgical method of craniopharyngiomas, radiotherapy and radiosurgery, and linked endocrine disturbances. a selected function of the ebook is the specific consciousness dedicated to the metabolic results of the affliction and similar remedies, together with weight problems and electrolyte disturbances, and to cognitive adjustments. This booklet could be of worth to oncologists, neurosurgeons, and endocrinologists via supporting in diagnostic workup, supply of applicable therapy, and administration of the intense metabolic and endocrine consequences.

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2009), posterior fossa (Bikmaz et al. 2009), lumbar spine (Lee et al. 2001), brainstem and basal ganglia (Novegno et al. 2002). Rare examples of epidural metastasis and patients with bilateral deposits have also been reported (reviewed in Frangou et al. 2009). It is unclear whether surgical manipulation contributes to dissemination, but it is worth noting that all reported metastases occurred in patients with suprasellar CP treated with transcranial approach but have never been documented in patients with an intrasellar lesion approached transsphenoidally.

2012). Moreover, expression of PTCH1 was detected within and surrounding the cell clusters, suggesting that secreted SHH protein may be acting over a distance as a morphogen (Andoniadou et al. 2012). So far, mutations in components of the HH pathway have not been described in human ACP. The demonstration that the SHH pathway is active in ACP may have important therapeutical implications. Several preclinical studies in mice have demonstrated the efficacy of SMO inhibitors in reducing tumour burden in mouse models for 44 F.

2012). These tumours were undifferentiated and did not express synaptophysin, a characteristic common with human ACP. Unexpectedly, however, the tumours were not YFP+ve, indicating that tumour cells were not the progeny of the mutated Sox2+ve stem cells. Further analyses revealed that Sox2+ve cells proliferated transiently and stop proliferating, giving rise to clusters with nuclear–cytoplasmic β-catenin accumulation that were similar to the typical clusters observed in human ACP. If the tumours are not derived from the mutated Sox2+ve cells, how do tumours form?

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Diagnosis and Management of Craniopharyngiomas: Key Current Topics by Andrea Lania, Anna Spada, Giovanni Lasio

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