By Andrea Lania, Anna Spada, Giovanni Lasio
This publication presents updated insurance of the main appropriate issues within the analysis and administration of craniopharyngiomas. After introductory dialogue of normal historical past and medical presentation, person chapters are dedicated to pathological and molecular facets, use of diagnostic imaging innovations, the surgical method of craniopharyngiomas, radiotherapy and radiosurgery, and linked endocrine disturbances. a selected function of the ebook is the specific consciousness dedicated to the metabolic results of the affliction and similar remedies, together with weight problems and electrolyte disturbances, and to cognitive adjustments. This booklet could be of worth to oncologists, neurosurgeons, and endocrinologists via supporting in diagnostic workup, supply of applicable therapy, and administration of the intense metabolic and endocrine consequences.
Read Online or Download Diagnosis and Management of Craniopharyngiomas: Key Current Topics PDF
Similar neurosurgery books
Issues because of trauma to the top, backbone, and peripheral nerves are one of the most typical visible via neurologists and neurosurgeons. This forty two bankruptcy e-book is the great, definitive paintings at the topic, delivering insurance on quite a lot of medical concerns. the second one version positive aspects thoroughly new sections on activities and neurologic trauma and iatrogenic trauma to enrich present finished sections on head trauma, spinal trauma, plexus and peripheral nerve accidents, post-traumatic soreness syndromes, environmental trauma, and posttraumatic sequelae and medicolegal facets.
This color atlas offers info on all significant acoustic neurinoma approaches, and is designed to enhance physicians' abilities during this forte. With greater than 50,000 new circumstances in keeping with yr around the world, acoustic neurinomas are one of the most typically saw skull-base tumours. also they are one of the so much hard for surgeons, in view that nice precision is required to defend the auditory nerve, the facial nerve and different severe buildings.
The sphere of neural transplantation is at an important degree, with very important scientific trials on transplantation in sufferers with Parkinson's affliction nearing crowning glory and novel, replacement techniques to fetal transplantation being constructed. This well timed publication brings jointly prime neuroscientists, clinicians, and cellphone and developmental biologists to debate using neural transplants in neurodegenerative problems, resembling Parkinson's ailment, Huntington's chorea, amyotrophic lateral sclerosis, a number of sclerosis and spinal wire damage.
Featured as a unmarried quantity, this can be a accomplished advisor to attainable nerve entrapment syndromes and their administration. each one bankruptcy covers a unmarried nerve, or crew of heavily comparable nerves, and is going over the scientific presentation, anatomy, actual examination, differential prognosis, contributing elements, injection strategies, neurolytic/surgical thoughts, remedies of perpetuating components, and problems.
- Cervical Spine II: Marseille 1988
- Spondylolisthesis: Diagnosis, Non-Surgical Management, and Surgical Techniques
- Neuroprotection and Regeneration of the Spinal Cord
- Revision Sinus Surgery
Extra resources for Diagnosis and Management of Craniopharyngiomas: Key Current Topics
2009), posterior fossa (Bikmaz et al. 2009), lumbar spine (Lee et al. 2001), brainstem and basal ganglia (Novegno et al. 2002). Rare examples of epidural metastasis and patients with bilateral deposits have also been reported (reviewed in Frangou et al. 2009). It is unclear whether surgical manipulation contributes to dissemination, but it is worth noting that all reported metastases occurred in patients with suprasellar CP treated with transcranial approach but have never been documented in patients with an intrasellar lesion approached transsphenoidally.
2012). Moreover, expression of PTCH1 was detected within and surrounding the cell clusters, suggesting that secreted SHH protein may be acting over a distance as a morphogen (Andoniadou et al. 2012). So far, mutations in components of the HH pathway have not been described in human ACP. The demonstration that the SHH pathway is active in ACP may have important therapeutical implications. Several preclinical studies in mice have demonstrated the efficacy of SMO inhibitors in reducing tumour burden in mouse models for 44 F.
2012). These tumours were undifferentiated and did not express synaptophysin, a characteristic common with human ACP. Unexpectedly, however, the tumours were not YFP+ve, indicating that tumour cells were not the progeny of the mutated Sox2+ve stem cells. Further analyses revealed that Sox2+ve cells proliferated transiently and stop proliferating, giving rise to clusters with nuclear–cytoplasmic β-catenin accumulation that were similar to the typical clusters observed in human ACP. If the tumours are not derived from the mutated Sox2+ve cells, how do tumours form?
Diagnosis and Management of Craniopharyngiomas: Key Current Topics by Andrea Lania, Anna Spada, Giovanni Lasio