Download e-book for kindle: The Intervertebral Disc: Molecular and Structural Studies of by Irving M. Shapiro, Makarand V. Risbud

By Irving M. Shapiro, Makarand V. Risbud

ISBN-10: 3709115345

ISBN-13: 9783709115343

ISBN-10: 3709115353

ISBN-13: 9783709115350

The intervertebral disc is a posh constitution that separates opposing vertebrae, allows quite a lot of movement, and incorporates excessive biomechanical forces. Disc degeneration results in a lack of functionality and is usually linked to excruciating pain.

Written by means of major scientists and clinicians, the 1st a part of the e-book offers a assessment of the elemental biology of the disc in health and wellbeing and ailment. the second one half considers thoughts to mitigate the results of disc degeneration and discusses the potential of engineering substitute tissues. the ultimate part is dedicated to ways to version basic improvement and elucidate the pathogenesis of degenerative disc disorder utilizing animal, organ and mobilephone tradition concepts.

The publication bridges the distance among the elemental and scientific sciences; the objective viewers comprises simple scientists, orthopaedists and neurologists, whereas whilst beautiful to the desires of graduate scholars, scientific scholars, interns and fellows.

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Additional resources for The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease

Example text

H. M. 5 Nm (Heuer et al. 2008). From in vitro experiments, there is a reduction of the outward bulging of the annulus fibrosus and an increase of disc height and intradiscal pressure (Heuer et al. 2008; van Deursen et al. 2001a, b). The decrease of outward bulging can be directly linked to the high tensile fiber stresses in the outer lamellae. The decrease of lateral bulging also explains the increase of disc height and intradiscal pressure. Although the strains observed in torsion may be too small to cause significant damage to the disc, a decrease in the failure loads have been observed when torsion is combined with compression and flexion/extension.

J Biomech 43(6):1017–1030 O’Connell GD, Johannessen W, Vresilovic EJ, Elliott DM (2007) Human internal disc strains in axial compression measured noninvasively using magnetic resonance imaging. Spine (Phila Pa 1976) 32(25):2860–2868 O’Connell GD, Guerin HL, Elliott DM (2009) Theoretical and uniaxial experimental evaluation of human annulus fibrosus degeneration. J Biomech Eng 131(11) O’Connell GD, Vresilovic EJ, Elliott DM (2010) Human intervertebral disc internal strain in compression: the effect of disc region, loading position, and degeneration.

In the healthy human annulus fibrosus, the water content is 50 %, collagen is approximately 70 % of the dry weight, and proteoglycans make up to 10 % of the dry weight (Eyre and Muir 1976; Eyre 1979). The annulus fibrosus is subjected to both tensile and compressive stresses during physiological loading. Consequently, it has high collagen content similar to other tension-bearing tissues such as tendon and ligaments. Proceeding from the outer to the inner annulus, there is an decrease in the ratio of collagens I to II, and the amount of proteoglycan rises.

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The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease by Irving M. Shapiro, Makarand V. Risbud

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